An Autonomous Agent

exploring the noosphere

Category: biology (Page 5 of 18)

p53: The Gene that Cracked the Cancer Code – Sue Armstrong

Sue Armstrong’s new book, p53: The Gene that Cracked the Cancer Code, is a fascinating summary of the many people and discoveries which led to our modern knowledge about p53. The book goes into detail about the conceptual struggles and breakthroughs which occurred over a period of several decades. The path to our current understanding was not linear and still continues to be a challenge. The best part about these accounts is the spirit and language with which Armstrong writes. She transforms a subject heavy with biological jargon into a great tale accessible to anyone with a general understanding of biology and genetics.

The book mentions several possible paths for the future of cancer therapy. I think the most interesting are those of prevention and finding a molecular band-aide. The efforts at cancer prevention should really be encouraged and insurance companies should start requiring yearly screenings. If we can achieve rates of discovery around 50-75%, that is solving half the problem. A molecular approach to stabilizing the p53 mutant sounds, to me, like an optimal solution. For an example, see this paper. The discovery of molecules which could safely enter the body and stabilize the mutant p53 — making it behave normally — would be a discovery of a lifetime.

Secular Cycles – Peter Turchin and Sergey A. Nefedov

Secular Cycles by Peter Turchin and Sergey A. Nefedov investigates the nature of biological and economic growth in combination with the characteristic social structures and power relationships unique to humans. This combination of Marxian and Malthusian analysis provides an interesting approach which can be developed to help predict future developments and understand how history develops.

The book (really an academic paper) is an analysis based on various data which have survived the ravages of time. It looks at cycles which occurred in various regions and times in the past, including Rome, France, England, and Russia. It shows how time after time humans progress, only to regress. And this “dis-integration” may be caused by either biological constraints and/or existing political structures. There also appears to be characteristic times which tend to correspond to successive generations or every other generation. And this wave or cyclical behavior is inherent in the complex system of homo-sapiens — being a social animal who spends 20+ years acquiring the knowledge and skills of ancestors.

I can only wish that more quantitative data were available to study ancient humans; ironically it is the “dis-integrative” phases of growth where data, observations, and history are destroyed and lost forever. Perhaps the next “integrative” phase of societal growth is a function of how much information is preserved from the previous “integrative” phase (think about Library of Alexandria). Formulaic conclusions based upon detailed and consistent data extending to the remote reaches of the past may forever be lost. Sometimes this data can be cleverly reconstructed (see here). Most of the time the data can not be obtained and this should serve to emphasize the importance of preserving the Noosphere for the sake of future societies.

The Evolution of Ecological Consciousness

The Evolution of Ecological Consciousness is a well made and must watch presentation by the Permaculture designer Andrew Faust of the Center for Bioregional Living. He summarizes many of the ideas presented by Carl and Dorion Sagan and Lynn Margulis. In addition, he presents many fascinating visions for a future living experience in conjunction with biology.

Planet Ocean (2012) – Yann Arthus-Bertrand and Michael Pitiot

I absolutely loved the stunning imagery and awe captured in Planet Ocean. Looking at the microscopic organisms blooming in the ocean, then witnessing the entire Gaia system interacting in complex ways, the perspectives are inspiring for scientists and artists. It was one of the best visual documentaries I have seen. Definitely worth watching!

Species Xchange

A big reason why it is so hard to fix and respond to environmental crises is the fact that societies lack a means to store ecological value in a monetary form. As a result, in the never-ending pursuit of growth and technological progress we rarely consider the growth and progress of other species. But how can we? Population statistics, ecological value, and other detailed data are rare or non-existent. We have very little quantitative data on the thousands of other species. And we don’t care. The average citizen can barely find time to consider the fate of the Rhino when he/she works 10 hours a day. We are stuck in fifth gear — moving full speed into the future despite the dire consequences of ignorance and a failure to act. The current relationship between humanity and the biosphere is reminiscent of parasitism or cancer. I just hope we are not yet in stage 4. Despite the reliance of our survival on other species, we continually threaten their existence — and indirectly our own.

The solution to the impending crises lies in a change of perception. The often quoted “survival of the fittest” ideology tends to cause people to forget about another important form of evolution — symbiosis. Cancer is the extreme version of “survival of the fittest” and parasitism at the cellular level. Cooperation through symbiosis however, is working together to get the job done (mitochrondria and the endosymbiotic theory). If we change the way we view nature, from “Man versus Nature” to “Man with Nature,” our problems will begin to vanish. The conception of the future will turn from a dismal apocalyptic world to one of harmonious mutualism. A symbiotic biological cooperation between our species and the other species of Earth, who are at our mercy, will forever change the course of history. The importance of symbiosis is becoming increasingly clear as a powerful survival mechanism in biological evolution and the future of homo sapiens may depend on its acceptance.

Brainstorming ways to establish a framework which intimately connects the economics of humans with that of their relatives in a symbiotic relationship, I believe one solution could be via the market. It involves creating a new asset class. By establishing shares of stock in species (or family/order) and having these shares trade in an exchange, the success of other species now becomes a potentially profitable industry for humans. At the same time benefiting the non-human species. Similar to humans trading shares of stock with theoretical values based on the work potential of organizations of labor producing members, the trading of species shares would be based upon the ecological value of biological organisms.

This Species Xchange would provide a means to store human labor potential (money) in the data collection, protection, monitoring, preservation, and development of any number of species. This funding would be initiated through an IPO for each species. I believe this would be symbiosis at its finest. Including other species in our financial decision making would fundamentally change the relationship humans have with their biological relatives.  By protecting the species humans rely on for ecological harmony, while at the same time providing them with a more “bio-diverse” basket of eggs to store their labor potential would, in effect, create a more dynamic and powerful investment system.

Since these shares would lack the legal power characteristic of corporate shares, the Species Xchange organization would guarantee the price per share. This guaranteed price per share would be calculated based on species reports published on a quarterly or semi-annual basis, similar to how corporations release 10K and 10Q reports. The calculation would be based upon various statistical and environmental attributes of the species, determined by experts, suitable for maintaining the harmony of the total ecological system. And this price could increase or decrease from quarter to quarter; depending on how the specific factors change. The only way the shares would be valueless, similar to corporate bankruptcy, was if the species went extinct — in effect providing a strong incentive to keep the species alive and prosperous.

The money raised in the IPO would go towards all manner of initiatives to fund and support the species. It would be managed by a group of people in a primus inter pares form of management. The goal of management would be to spend the money in such a way as to increase the value of the species in relation to all other species. This could include population measurement and control, biological research on the life cycle of the species, detailed studies on the role in the overall ecological network, etc…

For example, let’s say 100 million shares of Macropus Rufus are issued to the public. The IPO is priced at $20 per share. Thus, proceeds of $2 billion would go towards a fund established for the Macropus Rufus species. At the end of each quarter, a species report would be released detailing any changes in population, biological discoveries, and other details related to the status of the species. After each report, a new guaranteed price would be established by a set formula. Let’s say that new price is $22.50. Fast-forward through time and imagine a set of guaranteed prices: $22.50, $22.80, $21.00, $22.10, $25.00, etc… The set of guaranteed prices would form a set of lower bounds for the price series. The only reason an investor would redeem the shares would be in the event of an arbitrage if the price fell below the lower bound. However, it remains to be determined whether this would actually happen.

Perhaps all this seems silly, like something out of science fiction, and not feasible. Even though I would disagree, I think it is at least a step in the right direction. If more people can brainstorm practical ideas which join together humans and other species in a symbiotic relationship with current institutions, we may have a chance at preventing a catastrophic change in the biosphere. Harmony and balance can be restored with the right combination of creativity and institutional power.

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